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KMID : 0361120080220010021
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Korean Journal of Transplantation
2008 Volume.22 No. 1 p.21 ~ p.28
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The Post-transplant Lymphoproliferative Disorder after Renal Transplantation
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Paik Kyung-Hoon
Lee Suk-Koo
Yoo Keon-Hee
Chung Doo-Ryeon
Kim Won-Seog
Kang Hee-Gyung
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Abstract
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Post-transplant lymphoproliferative disorder (PTLD) is a B cell proliferative disorder that is associated with Eptstein-Bar (EBV). This is a heterogeneous group of conditions characterized by EBV-driven proliferation of B-lymphocytes in the face of impaired T-cell immune surveillance. While new treatment modalities are being tried with variable success, regular EBV surveillance and carefully monitored reduction of immunosuppression remain the mainstay of treatment. This paper reviews the current knowledge of this increasingly common complications in renal transplant recipients.
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KEYWORD
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Post-transplant lymphoproliferative disorder, Epstein-Barr virus, Renal transplantation
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